FROM MOLECULAR DEVELOPMENTAL BIOLOGY TO BIOMEDICINE, EVOLUTION
AND SYSTEMS BIOLOGY
UNIVERSITY OF MAASTRICHT
Molecular approaches in diagnostics and therapy of disease
This theoretical course discusses how the new knowledge
and new insights into research methods can be applied
to the development of new molecular diagnostics and
clinical methods of treatment (CMS). The advantages
and disadvantages of classical and new research strategies
will be described and illustrated using examples in
lectures given by recognised experts. These examples
will always be with reference to the major chronic
diseases and a multi-disciplinary approach. Four modules
of 2 weeks each:
and infectious disease
Central to this module is myocarditis, a disease
that leads to heart failure. Infection and chronic
inflammation are the key players in this syndrome.
The module will focus on how molecular-biological
research into this can lead to innovation in terms
of diagnostics and therapy.
This module will focus on asthma and multiple sclerosis.
An immunological disorder is the cause of both these
diseases. Special attention will be given to current
insight into the immunological mechanisms that leads
to new research for improvement of the diagnostics
micro-environment, consequences for treatment)
Surgery, radiation treatment and chemotherapy are
the conventional therapies for cancer. This is not
effective for almost half of the patients. The expectations
of immunotherapy for the treatment of cancer are
high. This module will focus on research into immunotherapy,
including immuno-cell therapy and vaccination.
disease: diabetes and its complications
This module will focus on the development of obesity
into insulin-resistant and type 2 diabetes and the
consequences for cardiovascular functioning, with
special emphasis on the role of hyperglycaemia, dyslipidaemia
and oxidative stress.
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